Publications

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Articles

Enhancing Proteasome Activity in T Cells Alleviates Exhaustion and Improves Antitumor Immunity

de Blas A, Andreatta M, Antoñana-Vildosola A, Velasco-Beltrán P, Egia-Mendikute L, Jimenez-Lasheras B, Bosch A, Barreira-Manrique A, Oyenarte I, Lee SY, Heuser-Loy C, Baldwin JG, Schelker RC, Martín-Santos A, Mastrogiovanni F, Azkargorta M, Elortza F, Sutherland JD, Torrano V, Aransay AM, Pérez-Gutiérrez L, Gros A, Carmona SJ, Gattinoni L, Ereño-Orbea J, Prieto-Fernández E, Palazon A. Enhancing Proteasome Activity in T Cells Alleviates Exhaustion and Improves Antitumor Immunity. Cancer Res. 2026 Mar 26.
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High-salt diet induces immune-independent re-differentiation, metabolic shut down and cell cycle arrest of melanoma

Lisowski C, Stumpf NE, Jobin K, Klaus D, Eichler M, Baumgart AK, Babyak O, Meißner M, Schröder A, Neubert P, Schmitt V, Michla M, Bozkurt S, Zurkovic J, Hinze D, Liebing J, Eckhardt M, Heuser-Loy C, Seep L, Heine A, Becker-Gotot J, Thiele C, Münch C, Becker T, Jantsch J, Wilhelm C, Hölzel M, Kurts C. Cell Death Dis. Dec 20, 2025
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Intercellular nanotube-mediated mitochondrial transfer enhances T-cell metabolic fitness and antitumor efficacy

Baldwin JG, Heuser-Loy C*, Saha T*, Schelker RC, Slavkovic-Lukic D, Strieder N, Hernandez-Lopez I, Rana N, Barden M, Mastrogiovanni F, Martin Santos A, Raimondi A, Brohawn P, Higgs BW, Gebhard C, Kapoor V, Telford WG, Gautam S, Xydia M, Beckhove P, Kontarakis Z, Corn JE, Iannacone M, Inverso D, Rehli M, Fioravanti J, Sengupta S, Gattinoni L. Cell. Nov 14, 2024 187(23):6614-6630.e21.
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LSD1 inhibition improves efficacy of adoptive T cell therapy by enhancing CD8+ T cell responsiveness

Pallavicini I, Frasconi TM, Catozzi C, Ceccaci E, Tiberti S, Haas D, Samson J, Heuser-Loy C, Nava Lauson CB, Mangione M, Preto E, Bigogno A, Sala E, Iannacone M, Mercurio C, Gattinoni L, Caruana I, Kuka M, Nezi L, Minucci S, Manzo T. Nat Commun. Aug 27, 2024 (15): 7366
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Ectopic LMO4 expression enhances CD8+ T cell stemness and tumor rejection by boosting IL-21-STAT3 signaling.

Schelker RC, Fioravanti J, Mastrogiovanni F, Baldwin JG, Li P, Chen P, Vadasz T, Spolski R, Rana N, Heuser-Loy C, Slavkovic-Lukic D, Pullugula S, Lin J-X, Oh J, Noronha P, Grandinetti P, Lecce M, Hesse L, Kocks E, Martin-Santos A, Gebhard C, Telford W, Ji Y, Restifo NP, Rehli M, Herr W, Leonard WJ, Gattinoni L. Signal Transduct Target Ther. Aug 9, 2024 9(1): 199.
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Conditional NKT cell depletion in mice reveals a negative feedback loop regulating CTL cross-priming

Heuser-Loy C*, Baumgart A-K*, Philipp M-S, Courrèges CJF, Thaiss CA, Hackstein C-P, Holland T, Evaristo C, Garbi N, Kurts C. J Immunol. Jan 1, 2024 212(1): 35-42.
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Inflammatory Cues Direct Skin-Resident Type 1 Innate Lymphoid Cells to Adopt a Psoriasis-Promoting Identity

Evers BDG, Hils M, Heuser C, Hoelge IM, Argiriu D, Skabytska Y, Kaesler S, Posch C, Knolle PA, Biedermann T. JID Innov. July, 2023 3(4): 100204.
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Renal Denervation Exacerbates LPS- and Antibody-Induced Acute Kidney Injury, but Protects from Pyelonephritis in Mice

Böhner AMC, Jacob AM, Heuser C, Stumpf NE, Effland A, Abdullah Z, Meyer-Schwesiger C, von Vietinghoff S, Kurts C. J Am Soc Nephrol. Oct, 2021 32(10): 2445-2453.
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Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells

Rosenbaum M, Gewies A, Pechloff K, Heuser C, Engleitner T, Gehring T, Hartjes L, Krebs S, Krappmann D, Kriegsmann M, Weichert W, Rad R, Kurts C, Ruland J. Nat Commun. May 28, 2019 (10): 2352.
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Prolonged IKKβ inhibition improves ongoing CTL antitumor responses by incapacitating regulatory T cells

Heuser C*, Gotot J*, Piotrowski EC, Philipp M-S, Courrèges CFJ, Otte MS, Guo L, Schmid-Burgk JL, Hornung V, Heine A, Knolle PA, Garbi N, Serfling E, Evaristo C, Thaiss F, Kurts C. Cell Rep. October 17, 2017 (21): 578-586.
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CD103+ Kidney Dendritic Cells Protect against Crescentic GN by Maintaining IL-10-Producing Regulatory T Cells

Evers BDG, Engel DR, Böhner AMC, Tittel AP, Krause TA, Heuser C, Garbi N, Kastenmüller W, Mack M, Tiegs G, Panzer U, Boor P, Ludwig-Portugall I, Kurts C. 2016. J Am Soc Nephrol. Nov 27, 2016 (11): 3368-3382.
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Localisation of N acetylaspartate in oligodendrocytes/myelin

Nordengen K, Heuser C, Rinholm JE, Matalon R, Gundersen V. Brain Struct Funct. March 1, 2015 220(2): 899-917.
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Exclusive CX3CR1 dependence of kidney DCs impacts glomerulonephritis progression

Hochheiser K, Heuser C, Krause TA, Teteris S, Ilias A, Weisheit C, Hoss F, Tittel AP, Knolle PA, Panzer U, Engel DR, Tharaux P-L, Kurts C. 2013. J Clin Inv. Sept 1, 2013 123(10): 4242–4254.
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Mouse model for pyelonephritis

Tittel AP, Heuser C, Kurts C. 2013. Curr Prot Immunol. Apr 1, 2013. 101: 15.23.1-9.
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Molecular Identification of GD3 as a Suppressor of the Innate Immune Response in Ovarian Cancer

Webb TJ, Li X, Giuntoli RL 2nd, Lopez PH, Heuser C, Schnaar RL, Tsuji M, Kurts C, Oelke M, Schneck JP. Cancer Res. May 26, 2012 72: 3744-3752.
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Functionally relevant neutrophilia in CD11c diphtheria toxin receptor transgenic mice

Tittel AP*, Heuser C*, Ohliger C, Llanto C, Yona S, Hämmerling GJ, Engel DR, Garbi N*, Kurts C*. Nat Meth. Feb 26, 2012 9: 385-390
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Kidney Dendritic Cells Induce Innate Immunity against Bacterial Pyelonephritis

Tittel AP, Heuser C, Ohliger C, Knolle PA, Engel DR, Kurts C. 2011. J Am Soc Nephrol. Aug 1, 2011 22: 1435-1441
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Christoph Heuser-Loy